Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Aβ region of amyloid precursor protein. Isolation of peptide transport system-6 from brain endothelial cells: therapeutic effects with antisense inhibition in Alzheimer's and stroke models. Antisense oligonucelotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: involvement of transcription factor Nrf2 and implications for Alzheimer's disease. ![]() Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in aged SAMP8 mouse brain. Treatment of experimental autoimmune encephalomyelitis with antisense oligonucleotides against the low affinity neurotrophin receptor. Delivery across the blood–brain barrier of antisense directed againt amyloid β: reversal of learning and memory deficits in mice overexpressing amyloid precursor protein. Interactions of cytokines with blood–brain barrier: implications for feeding. ![]() Blood–brain barrier and feeding: regulatory roles of saturable transport systems for ingestive peptides. Brain uptake of radio-labelled amino acids, amines and hexoses after arterial injection. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Review of mechanisms by which the BBB defines the neuroimmune system.īell, R. The blood–brain barrier in neuroimmunology: tales of separation and assimilation. Astrocyte–endothelial interactions at the blood–brain barrier. Demonstrates the role of pericytes in establishing the BBB and shows that barrier function is present even during the fetal period.Ībbott, N. Pericytes are required for blood–brain barrier integrity during embryogenesis. The blood–brain barrier/neurovascular unit in health and disease. Strategies to advance translational research into brain barriers. Thus, the BBB itself can be a therapeutic target. ![]() Such dysfunctions include BBB disruption as well as dysfunctions related to BBB transporters, neurovascular unit communication and secretion. The complexity of the BBB predisposes it to dysfunctions that can result in or promote disease. ![]() Manipulation of transporters, secretory functions, the extracellular pathways, and adsorptive transcytosis are examples of promising approaches to drug development. The complexity of the BBB complicates CNS drug delivery, but also provides many unique opportunities for drug delivery. Through transport, secretion and other mechanisms, the BBB relays information between the periphery and the CNS. The BBB also communicates with circulating immune cells and via blood-borne signals with the peripheral tissues. This communication informs the BBB of the needs of the CNS, allowing it to adapt to the needs of the CNS. The cells forming the BBB are in communication with other cells of the CNS, thus forming the neurovascular unit. The blood–brain barriers (BBBs) are dynamic, adaptable, interactive monolayers of cells, including endothelial, ependymal and tanycytic cells, that participate in central nervous system (CNS) protection, are responsible for CNS nutrition and homeostasis, and facilitate serum-based brain–body communications.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |